Chothia Antibody Numbering

abYsis supports all major numbering systems. The Chothia numbering scheme is based on Kabat, but places the insertions in CDR-L1 and CDR-H1 at the structurally correct positions.

Chothia Details

In addition to indels in CDR-L1 and CDR-H1 that are considered by the Chothia scheme, the 'Martin' scheme considers the structurally correct locations for indels in the Framework regions.

In detail:

H82a,b,c is moved to the structurally correct location of H72a,b,c.

An indel site at L52 in CDR-L2 is introduced.

This approach also corresponds with the AHo numbering scheme.

In the scheme below, locations of deleted residues are indicated with ().

The pre-1989/post-1997 Chothia numbering (the structurally correct version) throughout the chains follows;

Light chain
       0     1     2     3     4     5     6     7     8     9
      10    11    12    13    14    15    16    17    18    19
      20    21    22    23    24    25    26    27    28    29
      30    
      30A   30B   30C   30D   30E   30F
            31    32    33    34    35    36    37    38    39
      40    41    42    43    44    45    46    47    48    49
      50    51    52    53    54    55    56    57    58    59
      60    61    62    63    64    65    66    67    68    69
      70    71    72    73    74    75    76    77    78    79
      80    81    82    83    84    85    86    87    88    89
      90    91    92    93    94    95
      95A   95B   95C   95D   95E   95F   96    97    98    99
     100   101   102   103   104   105   106
     106A                                      107   108   109
Heavy chain
       0     1     2     3     4     5     6     7     8     9
      10    11    12    13    14    15    16    17    18    19
      20    21    22    23    24    25    26    27    28    29
      30    31    
      31A   31B
                  32    33    34    35    36    37    38    39
      40    41    42    43    44    45    46    47    48    49
      50    51    52
      52A   52B   52C   53    54    55    56    57    58    59
      60    61    62    63    64    65    66    67    68    69
      70    71    72    73    74    75    76    77    78    79
      80    81    82
      82A   82B   82C   83    84    85    86    87    88    89
      90    91    92    93    94    95    96    97    98    99
     100
     100A  100B  100C  100D  100E  100F  100G  100H  100I  100J
     100K  101   102   103

For more information, visit the web site of our collaborator Professor Andrew Martin, from which the information here was adapted: www.bioinf.org.uk/abs