LIGPLOT+

The original software for 2D representations of Ligand-Binding site interactions.


Ligplot+

This is the original software for 2D representations of Ligand-Binding site interactions.

With the latest version you can also flexibly compare:

  • Same protein with different ligands (specificity)
  • Homologous proteins with the same ligand (selectivity)
  • Homologous proteins with different ligands

Be guided in the analysis of selectivity and specificity through with detailed automated comparisons of homologous binding site interactions. Even analyse distant homologues with comparable binding sites by uploading a structure based sequence alignment.

     

    Want to know even more? Read our publication here.


      Homologous Proteins, Same Ligand   Analysis of Imatinib with homologues c-abl (2hyy) and c-kit (1t46).  The two sequences have 36% sequence identity. Conserved interactions predominate so unconserved positions have been highlighted

    Homologous Proteins, Same Ligand

    Analysis of Imatinib with homologues c-abl (2hyy) and c-kit (1t46). 
    The two sequences have 36% sequence identity. Conserved interactions predominate so unconserved positions have been highlighted


      Homologous Proteins, Different Ligands   Imatinib complex with homologue c-kit (2hyy) and amino pyrimidine reverse amide with lck (1t46). 37% sequence identity and 0.85 Tanimoto coefficient. The large difference in binding observed in 3D is reflected by Ligplot+. Again Ligplot+ highlights dis-similar interactions in this figure.

    Homologous Proteins, Different Ligands

    Imatinib complex with homologue c-kit (2hyy) and amino pyrimidine reverse amide with lck (1t46).
    37% sequence identity and 0.85 Tanimoto coefficient. The large difference in binding observed in 3D is reflected by Ligplot+. Again Ligplot+ highlights dis-similar interactions in this figure.